A simple, precise, accurate and economical spectrophotometric method has been developed for estimation of guaifenesin. The standard and sample solutions were prepared by using methanol as a solvent. Quantitative determination of the drug was performed at 273 nm. The linearity was established over the concentration range of 10-70 μg/ml. The correlation coefficient was found to be 0.998. Precision studies showed that % relative standard deviation was within range of acceptable limits (<2). The mean percentage recovery was found to be 99.22%. The proposed method has been validated as per ICH Q2 (R1) guidelines.
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